Managing diabetes is complex enough, adding sports on top of it seems too much for many. But what if you had an app that would help?

You’ll hear about

• the physiology of exercising with type 1 and type 2 diabetes
• what can go wrong
• hypoglycaemia and hiperglycaemia
• ketoacidosis
• tools to use to take control of the glucose level and do sports seriously, like there weren’t out there before

My guest today is Dr. Sam Scott, the Chief Scientific Officer at Enhance-d. An exercise physiologist with a vast background in researching diabetes and exercise in the UK, Canada, and Switzerland. He is an Advisor on the Exercise Physiology interest group leadership team for the American Diabetes Association. He used to be the Head of Research for Team Novo Nordisk the world’s first all-diabetes professional cycling team.

Enhance-d is a Swiss startup that develops an app for people with diabetes to exercise and even do professional sports safely by giving actionable, individualized insights drawn from a plethora of diabetes and exercise data.

Here you may follow their Beta and finale app release:
https://www.enhance-d.com

If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.

The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

If you are a person with diabetes, you already know that some drugs cannot be administered other than via injections. Today’s guest works on a solution for these medications to be taken from the inside of the cheek.

You’ll hear:

• how different kinds of drugs are absorbed
• why some drugs, macromolecular drugs, need to be delivered in injections
• how Obaris has overcome this problem
• how drugs such as Ozempic or Mounjaro could be administered painlessly

Dr. David Klein Cerrejon is the CEO of Obaris, a chemist with a PhD in pharmaceutical science specializing in drug delivery. Obaris is a Swiss startup, an ETH spin-off, that develops Octo-Patch, a small, painless patch, resembling an octopus sucker, that you can stick to the inner side of the cheek to administer drugs that are now available only in injections.

Here is more about Obaris:

https://obaris.ch/

If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.

The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

The small amount of brown fat can make you slim. Too much may kill you.

We just don't know who has it and how much.

But this may change with this test.

You’ll hear about

• brown fat but also white fat and beige fat
• what happens when we have too much brown fat or too little
• a new contrast agent to see brown fat on a CT scan
• that allows targeted therapies for cancer, diabetes, obesity,
• and even longevity

Dr. Andrej Babic is the CEO of Adiposs. A pharmacist with a PhD in medicinal chemistry who developed molecules for the diagnosis of diabetes, obesity, and cancer at the University of Geneva. He holds patents in medical imaging, photodynamic therapy, and nanotechnology.

Adiposs is a Swiss startup that develops ImageBAT, a first-in-class CT contrast agent for brown fat. This can be a game changer in obesity treatments, metabolic diseases, diabetes type 2, and cancer.

https://adiposs.com

If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.

The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

He dropped his engineering job to run 5 Ironman triathlons in 5 countries

for a cause.

But he did not foresee he would gather so many scientists on the way

that try to find a way to mitigate dementia

You’ll hear

• what does it take to run an Ironman triathlon
• how his family coped with his father’s Alzheimer’s
• how he united several startups and researchers to launch a study on the impact of lifestyle on the epigenetic level – to mitigate dementia

My guest today is Hassan Fadli, a materials engineer with 20 years of experience as a technology lead in the solar energy industry. But we’re not going to speak about photonics. His family history made him turn his life upside down.

He’s founded "5 Ironmans to Beat Alzheimer’s”, a non-profit initiative to run 5 Ironman triathlons in 5 countries in one year. They film a documentary about it, also interviewing dementia specialists, societies, patients, and families in all these countries. After Switzerland and Portugal, there are 3 races ahead in 2024:

in France, Nice – on June the 16 UPDATE: finished and beat his record!
in Sweden, Kalmar – on August the 16
and Spain, Calella-Barcelona – on October the 6th

Follow his Ironman races at:

https://www.5ironmansbeatalzheimer.com/en

If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.

The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

Can the Dark Genome have the answer to any disease?

And if you are wondering, what is the dark genome, you are not alone. And it is absolutely fascinating.

Some scientists believe that the dark matter of the genome – previously called junk genome – might have the answer to many, many diseases.

With the potential to cure them completely.

Today we are speaking about heart fibrosis and also:

• the richness of the regulatory genome
• its function: as a kind of software for the human body
• RNA therapies that are targeted, non-toxic, fast in development
• an absolutely new approach to drugs

Dr. Samir Ounzain is the CEO of HAYA Therapeutics. A molecular biologist who’s researched dark genome and its roles for over 15 years. While a postdoc at Lausanne University Hospital (CHUV), he discovered hundreds of long-non-coding RNAs.

HAYA Therapeutics selected one of them, called Wisper, to develop a highly targeted drug to address cardiovascular disease. That's for starters. They already work on lung fibrosis, cancer microenvironment, liver, pancreas, and kidney. They are based in both Lausanne and San Diego.

https://www.hayatx.com/

If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.

The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

Haven’t heard about breathing rate tracking yet?

Listen up.

You won’t need much:

just your headset and an app.

In this episode, you’ll hear about

• training plans based on breathing
• teaching ML models to recognize breathing patterns
• huge breathing data sets
• and how will you be able to use them to improve your training efficiency

Dr. Patrick Helfenstein is the co-founder and Chief Technical Officer at BreezeLabs. A physicist originally, with over a decade of research experience in both academia and industry he embraced Machine Learning. Just wait until he starts speaking about it.

BreezeLabs is a pre-seed stage Swiss startup that promises runners better optimised training by adding breathing rate tracking. No additional wearable needed, just a headset with a mic and their AI models will do the rest.

Here’s more about them:

https://www.breezelabs.ai/

If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.

The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

Challenging an over 100-year-old histology technic that is prone to false negatives.

In cancer diagnostics.

My guest aims to take histopathology departments from the 20th century into the 21st century, where they belong.

From slicing biopsy samples into 3D.

From a manual preparation to a robotic one.

Where all abnormalities will be pointed out and counted by AI.

And human physicians will see inside the whole sample in 3D.

Let's get down to the cell level.

You’ll hear

• what happens to your biopsy samples
• why the current histopathology standard is prone to misses
• how do you see inside the tissue in 3D and see 400 times more cells
• what’s so fascinating about watching cells and tissues under the microscope
• and more

Dr. Francesca Catto, the CEO of IMAI. With a background in Medical Biotechnology and Molecular Medicine, she fell in love with histopathology just to challenge it, when her research showed the current ways are not enough.

IMAI is a pre-seed stage Swiss medtech startup. They develop an automated robotic platform for faster 3D analysis of tumor tissues. Supported with AI, they avoid false negatives and offer better cancer detection.

https://www.imai-medtech.com/

If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.

The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

Another silent killer on the X-Health.show.

Undetected in too many instances.

Slowly taking away the balance. Implementing pain.

Starting at the feet and unstoppable, if not treated.

In this episode, you’ll hear about

• diabetic neuropathy
• the millions of people it concerns
• why the current treatment is simply not enough
• what change wearing a smart sock for 20 minutes brings
• and all these nerves connected to the brain involved in walking

My guest today is Dr. Greta Preatoni, the CEO of MYNERVA. She’s both a neuroscientist and a neuroengineer who did her research in diabetic neuropathy. She can awesomely speak about the neural pathways involved in sensing and movement.

MYNERVA is an early-stage Swiss startup, a spin-off from the ETH, Zurich. They develop a pleasant, as they emphasize, non-invasive nerve stimulation device for people with diabetic neuropathy to kill pain and walk without problems.

https://www.mynervamedical.com/

If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.

The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.