After a pregnant woman is found sexually assaulted, strangled and dumped in her bathtub in New Hampshire attempts at a DNA match are unsuccessful. 10 Years later a presentation on another unsolved homicide, in a similar manner, helps investigators to connect the dots.

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Paul is woken when two assailants enter his home in the middle of the night. After the intruders stab him multiple times, they set his house on fire and leave Paul for dead. Tressell is on a fishing trip with two of his friends when their boat capsizes 80 miles off shore. The men are forced to cling to the boat for over 8 days awaiting rescue. Melissa is on her way home when she is robbed and imprisoned in the trunk of her car. After withdrawing funds from an ATM, the assailant pushes the car into a lake with Melissa still locked inside.

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On the south side of St. Louis, a series of sexual assaults appears to follow the exact same pattern - leading police to dub the perpetrator, "The South Side Rapist." The last step in his modus operandi...was to disappear completely.