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The story is set in 1888. The Sign of the Four has a complex plot involving service in India, the Indian Rebellion of 1857, a stolen treasure, and a secret pact among four convicts ("the Four" of the title) and two corrupt prison guards. It presents the detective's drug habit and humanizes him in a way that had not been done in the preceding novel, A Study in Scarlet (1887). It also introduces Doctor Watson's future wife, Mary Morstan.

A Study in Scarlet is an 1887 detective novel by Scottish author Arthur Conan Doyle. The story marks the first appearance of Sherlock Holmes and Dr. Watson, who would become the most famous detective duo in popular fiction.

The story begins with a visit to 221B Baker Street from Steve Dixie, a black man and a cowardly ruffian who warns Sherlock Holmes to keep away from Harrow. Although Dixie has come to intimidate Holmes, Holmes secures Dixie's future cooperation by threatening to tell what he knows about the suspicious Perkins death involving Dixie. Dixie's boss is Barney Stockdale, and he must be connected with the Harrow Weald case, of which Holmes has just learnt from a message from Mary Maberley, a lady who lives at Three Gables, a house at Harrow Weald.

Holmes receives an odd letter that makes reference to vampires. Mr. Robert Ferguson, who comes to 221B Baker Street the next morning, has become convinced that his Peruvian second wife has been sucking their baby son's blood. By his first wife, he has a 15-year-old son named Jack, who suffered an unfortunate accident as a child and now, although he can still walk, he does not have the full use of his legs. After the bloodsucking began, Jack has unaccountably been struck twice by his stepmother, although Mr. Ferguson cannot imagine why.

In January 1903, at Baker Street, James M. Dodd sees Holmes about a missing friend, Godfrey Emsworth. Dodd and Emsworth served together in the Imperial Yeomanry in South Africa during the Second Boer War, which has only just ended. Emsworth was wounded during this war. Dodd has not seen him since the report of his injury leading Dodd to believe something is amiss.

Sherlock Holmes is hired by a retired art supply dealer from Lewisham, Josiah Amberley, to look into his wife's disappearance. She has left with a neighbour, Dr. Ray Ernest, taking a sizeable quantity of cash and securities. Amberley wants the two tracked down.

Holmes is visited by Mrs. Merrilow, a landlady from South Brixton who has an unusual lodger who never shows her face. She saw it once accidentally and it was hideously mutilated. This woman, formerly very quiet, has recently taken to cursing in the night, shouting "Murder, murder!" and "You cruel beast! You monster!" Also, her health has taken a turn for the worse, and she is wasting away.

The Hound of the Baskervilles is the third of the four crime novels written by Sir Arthur Conan Doyle featuring the detective Sherlock Holmes. Originally serialised in The Strand Magazine from August 1901 to April 1902, it is set largely on Dartmoor in Devon in England's West Country and tells the story of an attempted murder inspired by the legend of a fearsome, diabolical hound of supernatural origin. Sherlock Holmes and his companion Dr. Watson investigate the case.

Watson arrives at 221B Baker Street where the page boy Billy shows him a wax effigy of Holmes placed near a curtained window in the sitting room. The effigy produces a shadow on the curtain that, when viewed from outside, is the unmistakable profile of Sherlock Holmes. Using this visual trick, Holmes aims to give a perfect target to a would-be murderer with a rifle. Holmes names his murderer as Count Negretto Sylvius, the diamond thief he has been following in disguise. He gives the criminal's address to Watson, then sends the doctor out the back for the police.

The Valley of Fear is the fourth and final Sherlock Holmes novel by Sir Arthur Conan Doyle. It is loosely based on the Molly Maguires and Pinkerton agent James McParland. The story was first published in the Strand Magazine between September 1914 and May 1915. The first book edition was copyrighted in 1914, and it was first published by George H. Doran Company in New York on 27 February 1915, and illustrated by Arthur I. Keller.

Head trainer John Mason from Shoscombe Old Place, a racing stable in Berkshire, comes to Holmes about his master, Sir Robert Norberton. Mason thinks he has gone mad. Sir Robert's sister, Lady Beatrice Falder, owns Shoscombe, but it will revert to her late husband's brother when she dies. The stable has a horse, Shoscombe Prince, who Sir Robert hopes will win the Derby. He would be out of debt if that actually happened.

Neil Gibson, the Gold King and former Senator from "some Western state", approaches Holmes to investigate the murder of his wife Maria in order to clear his children's governess, Grace Dunbar, of the crime. It soon emerges that Mr. Gibson's marriage had been unhappy and he treated his wife very badly. He had fallen in love with her when he met her in Brazil, but soon realised they had nothing in common. He became attracted to Miss Dunbar; since he could not marry her, he had attempted to please her in other ways, such as trying to help people less fortunate than himself.

Holmes is enjoying his retirement in Sussex when one day at the beach, he meets his friend Harold Stackhurst, the headmaster of a nearby preparatory school called The Gables. No sooner have they met than Stackhurst's science teacher, Fitzroy McPherson, staggers up to them, clearly in agony and wearing only an overcoat and trousers. He collapses, manages to say something about a "lion's mane", and then succumbs. He is observed to have red welts all over his back, possibly administered by a flexible weapon of some kind, for the marks curve over his shoulder and round his ribs.

According to Dr. Watson's opening narration, this story is set at "the latter end of June, 1902 ... the same month that Holmes refused a knighthood for services which may perhaps some day be described." This is a parallel to the knighthood of Arthur Conan Doyle around the same time.

A man named Trevor Bennett comes to Holmes with a most unusual problem. He is Professor Presbury's personal secretary, and Mr. Bennett is also engaged to the professor's only daughter, Edith. Professor Presbury is himself engaged to a young lady, Alice Morphy, a colleague's daughter, although he himself is already 61 years of age. Their impending marriage does not seem to have caused a great scandal, so that is not Mr Bennett's problem. Nonetheless, the trouble seems to have begun at about the time of Professor Presbury's and Alice's engagement.

The Book of Jude is the penultimate book of the New Testament as well as the Christian Bible. It is traditionally attributed to Jude the Apostle, brother of James the Just, and thus possibly brother of Jesus as well.

The Book of Revelation is the final book of the New Testament (and consequently the final book of the Christian Bible). Its title is derived from the first word of the Koine Greek text: apokalypsis, meaning "unveiling" or "revelation". The Book of Revelation is the only apocalyptic book in the New Testament canon. It occupies a central place in Christian eschatology.

The Third Book of John is the third-to-last book of the New Testament and the Christian Bible as a whole, and attributed to John the Evangelist, traditionally thought to be the author of the Gospel of John and the other two epistles of John. The Third Epistle of John is a personal letter sent by "the elder" to a man named Gaius, recommending to him a group of Christians led by Demetrius, which had come to preach the gospel in the area where Gaius lived.

The Second Book of Thessalonians is a book from the New Testament of the Christian Bible. It is traditionally attributed to Paul the Apostle, with Timothy as a co-author. Modern biblical scholarship is divided on whether the epistle was written by Paul; some scholars believe Paul wrote this epistle, but others reject its authenticity based on what they see as differences in style and theology between this and the First Epistle to the Thessalonians.

The Epistle to the Colossians is the twelfth book of the New Testament. It was written, according to the text, by Paul the Apostle and Timothy, and addressed to the church in Colossae, a small Phrygian city near Laodicea and approximately 100 miles from Ephesus in Asia Minor. Some scholars have increasingly questioned Paul's authorship and attributed the letter to an early follower instead, but others still defend it as authentic. If Paul was the author, he probably used an amanuensis, or secretary, in writing the letter possibly Timothy.