The Peptide Podcast cover art

The Peptide Podcast

The Peptide Podcast

By: The Peptide Queen
Listen for free

About this listen

 The Peptide Podcast makes health and wellness decisions SIMPLE, FAST, and FUN. In less than 15 minutes each weekday, you'll get accurate, unbiased updates on peptides—from disease prevention and performance health to anti-aging and more. Hosted by The Peptide Queen, a clinical pharmacist with more than 15 years of experience, the show cuts through internet confusion to give you clear, reliable information so you can choose what's best for you.This website and its content are copyright of The Peptide Podcast - All rights reserved. Any redistribution or reproduction of part or all of the contents in any form is prohibited. Alternative & Complementary Medicine Exercise & Fitness Fitness, Diet & Nutrition Hygiene & Healthy Living
Episodes
  • Nutrient Tips While on GLP‑1 Medications

    Nutrient Tips While on GLP‑1 Medications
    Nov 13 2025

    Thanks for listening to The Peptide Podcast.

    Today we're going to talk about something that's becoming really important for anyone taking medications like Ozempic, Wegovy, or other GLP‑1 receptor agonists. You probably already know the benefits of GLP-1s—smaller appetite, better blood sugar control, and noticeable weight loss. But here's the catch: eating less can sometimes mean you're also taking in fewer essential vitamins and minerals that your body needs.

    In this episode, we're going to explore how to make sure every bite counts and when it might make sense to consider supplements.

    Read the Full Episode Transcript:
    https://pepties.com/nutrient-tips-while-on-glp-1-medications/

    Dr. Nikki's Qualifications:
    https://bifat.life/about/

    Related Links/Products Mentioned:
    Peptide Podcast Partners Page
    https://pepties.com/partners/

    BioLongevity Labs (Purchase Peptides online)
    Use our link and enter COUPON CODE: PEPTIDEPODCAST at checkout to receive 15% off your total order
    https://go.biolongevitylabs.com/aff_c?offer_id=1&aff_id=1582&aff_sub=PEPTIDEPODCAST

    Momentous Supplements (we use Creatine, Vital Aminos, Whey Protein)
    https://crrnt.app/MOME/OqGQOxGA

    LMNT – More Salt, Not Less.
    https://elementallabs.refr.cc/default/u/johnjavit

    Thorne Supplements (we use Omega-3 with CoQ10, Red Yeast Rice, Zinc)
    https://get.aspr.app/SH1KvW

    Organifi Creatine and Shilajit Gummies
    http://rwrd.io/rlbkajm?c

    MitoZen (methylene blue for Cognitive Function, Anti-Aging, Mental Clarity)
    https://www.mitozen.com/ref/cnlwiztypt/

    For skin and hair health (Copper Tripeptide-1)
    Visit Luminose by Entera for an exclusive offer for Peptide Podcast listeners!
    ** Promo code PEPTIDEPODCAST at checkout for 10% off an order or 10% off the first month of a subscribe-and-save. **
    https://www.enteraskincare.com/?rfsn=8906839.f93c72


    📚 Free Information:

    A Comprehensive Guide to the Top 27 Peptide Therapies
    https://pepties.com/a-comprehensive-guide-to-the-top-27-peptide-therapies-how-they-work-benefits-and-side-effects/

    The Ultimate Peptide Therapy Guide
    https://pepties.com/the-ultimate-peptide-therapy-guide/

    Peptide Injections: How Do You Inject Yourself With Peptides?
    https://pepties.com/guide-to-injecting-peptides/

    Top Episodes:
    Injectable BPC-157 vs Oral BPC-157
    https://pepties.com/injectable-bpc-157-vs-oral-bpc-157/

    NAD+
    https://pepties.com/nad/

    FAQs About Tirzepatide
    https://pepties.com/faqs-about-tirzepatide/
    Show More Show Less
    8 mins
  • ATX-304: Exercise In A Bottle

    ATX-304: Exercise In A Bottle
    Nov 6 2025
    Welcome to The Peptide Podcast. If you want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going. https://pepties.com/partners/ Before we jump in, I want to quickly address a few comments I have received about the content here. Normally, I wouldn't spend time on something like this, but just for clarity — I have over nine years of formal education, including a Doctorate in Pharmacy, and sixteen years of clinical experience. That includes serving as an adjunct professor at a U.S. pharmacy school and working in oncology and inflammatory disease at a teaching hospital. And yes — for now, you just hear my voice, but that may change. I do plan to incorporate video in the future; I've simply held off because it takes significantly more time to produce, and my priority has been getting the education out to you consistently. Remember, the content is free and meant for education. If it's not for you, that's completely fine — you don't have to listen. It takes a lot of time and energy to put this together, and tuning in is entirely your choice. For my other listeners, thank you for your support and gratitude over the past few years. Now, today we're diving into a compound ATX‑304. It's often referred to as "exercise in a pill". And after we go through the science together you'll see why. We'll cover the back‑story, how it works, how it differs from typical mitochondrial supplements, animal and human data so far, who this may and may not be for — and importantly, what to watch out for. The Backstory & Why It's Getting Attention ATX-304, was first developed in Sweden by Betagenon AB as a small-molecule AMPK activator designed to mimic the metabolic benefits of exercise and caloric restriction — with the goal of improving obesity, insulin resistance, and overall metabolic health. Early preclinical work in obese and diabetic mice showed impressive results, including better glucose uptake, enhanced fat-burning, improved insulin sensitivity, and even cardiovascular benefits. Human data followed in 2016–2017, where people with type 2 diabetes already on metformin took ATX-304 for about 28 days. Those studies showed reductions in fasting and plasma glucose, improved insulin resistance, and strong safety and tolerability. Today, Betagenon has evolved into Amplifier Therapeutics, and ATX-304 is now in Phase 2 development for metabolic, cardiovascular, and liver-related conditions, with ongoing work to refine oral delivery and broaden its potential uses. What exactly does AMPK do? Think of AMPK as a fuel gauge for your cells. When your cells are running low on energy (like when you haven't eaten, exercised, or your cells are stressed), AMPK turns on. When it's on, it tells the cell to stop storing energy (less fat and cholesterol production), start using energy (burn sugar and fat for fuel), and clean up damaged parts (autophagy, or cellular housekeeping). Basically, AMPK flips the switch from "energy saving" mode to "energy spending" mode, similar to how your body behaves during exercise or fasting. If AMPK is off or underactive, your cells tend to store energy instead of using it, which contributes to weight gain, insulin resistance, and low metabolic activity. So, activating AMPK — like with ATX‑304 — is like giving your body a nudge to burn energy, improve metabolism, and clean up the cells, even without intense exercise. And beyond just turning on AMPK, ATX‑304 also acts as a mild mitochondrial activator, meaning it helps the cell's "power plants" (mitochondria) run more optimally, increasing energy expenditure. Because of this mechanism, ATX‑304 is sometimes called an "exercise mimetic." Even though it's not a substitute for movement, it triggers many of the same downstream pathways. How It Differs From Mitochondrial "Supplements" There are many supplements out there that claim "boost mitochondria" (e.g., PQQ, CoQ10, NAD precursors). These may support mitochondrial health or function, but typically they don't change the body's energy‑balance set‑point or shift you into a state of enhanced energy usage. ATX‑304, however, directly activates AMPK (the master switch) and supports mitochondrial output — so you get signaling plus hardware improvement. This dual action is what sets ATX‑304 apart. Also: many mitochondrial supplements lack robust human metabolic‑dysfunction data; ATX‑304 has animal + early human trial data. What About Safety? In human trials (~28 days, T2D patients on metformin) ATX‑304 was safe, well tolerated, lowered fasting plasma glucose and insulin resistance. But because it's still early stage, long‑term safety and outcomes (fat‑loss, muscle preservation beyond short term, cardiovascular endpoints) are not fully proven yet. One of the most exciting things about ATX‑304 is that it encourages the body to burn fat while sparing lean ...
    Show More Show Less
    8 mins
  • Finding the Right Fit: Semaglutide, Tirzepatide, or Retatrutide

    Finding the Right Fit: Semaglutide, Tirzepatide, or Retatrutide
    Oct 30 2025
    Today, we're tackling a question that comes up often in peptide, weight loss, and nutrition clinics: why does one person see great results with semaglutide, while another responds better to tirzepatide—or even retatrutide? If you want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going. https://pepties.com/partners/ All three peptides target the incretin system, but they act in slightly different ways—and those differences can dramatically affect outcomes. Let's start with the basics. Semaglutide is a GLP-1 (glucagon-like peptide-1) receptor agonist. It mimics the gut hormone GLP-1, which increases insulin when blood sugar is high (to help lower blood sugar), suppresses glucagon (which also decreases blood sugar), and slows gastric emptying. It also enhances satiety—so you feel full longer and eat less. Tirzepatide is a dual agonist, acting on both GLP-1 and GIP receptors. GIP—glucose-dependent insulinotropic polypeptide—also helps with insulin secretion to lower blood sugar, increases fat metabolism, and may reduce some of the GI side effects seen with GLP-1 alone. Retatrutide, the newest in the lineup, is a triple agonist that targets GLP-1, GIP, and glucagon receptors. Retatrutide lightly activates the glucagon receptor while strongly activating GLP-1 and GIP receptors, which help regulate blood sugar and boost insulin secretion. This keeps blood sugar stable—or even improves it. Beyond blood sugar, glucagon also ramps up metabolism and calorie burning. By gently engaging glucagon receptors, retatrutide can increase energy expenditure and support fat loss without triggering large blood sugar spikes. So how do you decide which one might work best? Let's walk through common clinical situations. Patients with Hypothyroidism Let's talk about hypothyroidism. People with hypothyroidism often have slower metabolism, making weight loss more difficult even with a balanced diet. Low thyroid hormone levels slow calorie burning and energy use, so weight gain can occur more easily. For these patients, semaglutide is a reliable starting point—it helps regulate appetite and caloric intake. If progress plateaus, tirzepatide or retatrutide may provide an edge by boosting energy expenditure and fat oxidation, essentially "jump-starting" a slower metabolism. Patients with PCOS (Polycystic Ovary Syndrome) What about patients with PCOS (polycystic ovary syndrome)? Insulin resistance is common in PCOS, often leading to higher androgen levels (e.g., testosterone) and symptoms like irregular periods, acne, and excess hair growth. Hormonal changes also affect appetite-regulating hormones, increasing hunger and cravings. Both GLP-1 and dual agonists have proven effective in managing metabolic and reproductive aspects of PCOS. Typically, we start with semaglutide to improve weight, insulin sensitivity, androgen levels, and menstrual regularity. After a few months, if weight loss plateaus or cravings remain high, we may switch to tirzepatide. The added GIP activity enhances fat metabolism, insulin control, and may further support hormone regulation and ovulation. The key is starting with what's well-studied and tolerated, then stepping up if additional metabolic or reproductive support is needed. Type 2 Diabetes (T2DM) The next medical condition I'd like to talk about is type 2 diabetes (T2DM). Weight gain in T2DM often stems from insulin resistance. Cells don't respond effectively to insulin, prompting the pancreas to relelase more. High insulin levels encourage fat storage, particularly around the abdomen, while elevated blood sugar can increase hunger and cravings. Some diabetes medications, like insulin or sulfonylureas (e.g., glipizide or glyburide), can also contribute to weight gain. All three drugs lower blood sugar and promote weight loss, but tirzepatide currently shows the strongest combined A1c reduction (average blood sugar over the past 2 to 3 months) and weight loss. GIP and GLP-1 work together to enhance insulin response more effectively than GLP-1 alone. Retatrutide is in phase 3 trials, with potential FDA approval as early as 2027. Its glucagon receptor activity may offer additional glucose regulation and energy expenditure benefits. Patients with >15% Weight Loss Goals Okay, let's talk about weight loss goals and how this ties into the decision process for choosing a weight loss medication. For those patients looking to lose more than 15% of their total body weight, tirzepatide or retatrutide are likely to deliver greater results. Clinical data show semaglutide can achieve up to 15% total weight loss while tirzepatide can achieve up to 22% and retatrutide up to 24%. That said, semaglutide remains a highly effective option for weight loss. However, if progress begins to plateau, transitioning to a dual or triple agonist may help restart weight loss and push past that plateau. ...
    Show More Show Less
    13 mins
No reviews yet
In the spirit of reconciliation, Audible acknowledges the Traditional Custodians of country throughout Australia and their connections to land, sea and community. We pay our respect to their elders past and present and extend that respect to all Aboriginal and Torres Strait Islander peoples today.