The Matt Walker Podcast

By: Dr. Matt Walker
  • Summary

  • The Matt Walker Podcast is all about sleep, the brain, and the body. Matt is a Professor of Neuroscience at the University of California, Berkeley. He is the author of the book, Why We Sleep and has given a few TED talks. Matt is an awkward British nerd who adores science and the communication of science to the public.

    © 2025 The Matt Walker Podcast
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Episodes
  • #92 - The Healing Powers of Sleep
    Feb 17 2025

    This week Matt explores dreams, questioning if their specific content matters beyond the normal benefits of REM sleep. This episode examines dreaming's significance for creativity, memory integration, and its role as emotional first aid.

    The discussion then introduces a "hot off the press" study showing how dreams might help us shed unwanted memories, with insights into how REM sleep acts as a nocturnal soothing balm for emotional distress. The episode shares how REM sleep can take the painful edges off traumatic experiences, especially when dreams engage with the emotional content.


    Please note that Matt is not a medical doctor, and none of the content in this podcast should be considered medical advice in any way, shape, or form, nor prescriptive in any way.

    One of our sponsors this week is the biochemical electrolyte drink company LMNT, and they are very kindly offering eight free sample packs when you purchase any one of their orders at drinklmnt.com/mattwalker. LMNT is an electrolyte sports drink that I can get behind - it's created from the basis of science, and it has no sugar, no coloring, and no artificial ingredients – all qualities that are so important to maintaining your blood biochemical balance. If you want to give LMNT a try, just head on over to drinklmnt.com/mattwalker and get your eight free samples with your first purchase.

    Matt will be the first to tell you that launching his sleep-related merchandise sales was incredibly smooth, thanks to our new sponsor Shopify and their integrated sales and inventory system. And now, just for you, Shopify is generously offering an exclusive trial at shopify.com/mattwalker. Whether it's online or in-person sales, Shopify simplifies it all. So, be sure to stop in at shopify.com/mattwalker to start your exclusive journey now!


    Matt’s good friend Dr. Peter Attia has helped develop David, a revolutionary new protein bar, and a sponsor of today’s episode! 28g of protein, 0g sugar, only 150 calories – the best ratio EVER! Amazing taste, six flavors, incredibly satiating, and a great source of the protein that helps build muscle, manage metabolic health, and keep you full. Visit davidprotein.com/mattwalker now for an amazing deal: Buy 4 cartons, and get a 5th FREE! . Hurry! Your new favorite protein bar awaits!

    As always, if you have thoughts or feedback you’d like to share, please reach out:

    Matt: Instagram @drmattwalker, X @sleepdiplomat,

    YouTube https://www.youtube.com/@sleepdiplomatmattwalker9299

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    23 mins
  • Ask Me Anything Part 15: Beauty Sleep, Naps, 3 AM Wake-Ups & Axl Rose with Dr. Eti Ben Simon
    Feb 10 2025

    In their latest AMA episode, Matt and Eti address listener questions ranging from "beauty sleep" to 3 AM awakenings. They explore the scientific evidence supporting sleep's crucial role in skin health and perceived attractiveness, citing studies on the effects of sleep deprivation. The cognitive benefits of napping are discussed, highlighting its ability to enhance learning and memory consolidation. They also delve into the remarkable neural activity of deep non-REM sleep, including synchronized neuron firing and accelerated memory replay. The common concern of sleep debt is also a key topic.

    The discussion then turns to practical strategies for managing disruptive midnight awakenings. Our hosts debunk common myths and explain the physiological factors involved, such as body temperature fluctuations and adenosine clearance. They provide evidence-based techniques to quiet the mind and promote a return to sleep, including controlled breathing, non-sleep deep rest, and cognitive approaches. Finally, they touch on the concept of "hypnopedia" (in-sleep learning), largely refuted by research, and the more promising technique of targeted memory reactivation, which uses sleep cues to enhance memory.

    Please note that Matt is not a medical doctor, and none of the content in this podcast should be considered medical advice in any way, shape, or form, nor prescriptive in any way.

    Tired of untrustworthy protein shakes? Show sponsor Puori prioritizes quality: hormone-free, GMO-free, and pesticide-free. Every batch is third-party tested for 200+ contaminants - you can even scan the QR code for lab results! Matt recommends the addictive dark chocolate flavor with 21g of protein. Ready to experience the Puori difference? Matt’s listeners get 20% off, so visit puori.com/mattwalker today!

    Another great sponsor of the show is AG1, a comprehensive nutritional drink trusted by thousands worldwide, including Matt! For nearly four years and counting, he has relied on AG1 to fuel his post-workout routine with its powerhouse blend of over 75 essential minerals, vitamins, probiotics, and prebiotics, meticulously crafted to support your daily nutritional needs. AG1 is registered and approved by the Therapeutic Goods Administration, boasting GMP badges for quality assurance. As a special offer for our listeners, when you try AG1, you'll receive a complimentary one-year supply of both Vitamin D and K2, and with your first subscription, you'll also receive five free AG1 travel packs! Visit AG1 to explore AG1's range of offerings and claim your exclusive offer.

    Another sponsor, 23andMe, provides genetic insights into health and sleep, and Matt, who has used it for eight years to understand genetic risks, is impressed by their sleep-focused data. With details on chronotype—whether you’re genetically more inclined to be a morning person or night owl—along with insights on sleep quality, depth, and insomnia risk, 23andMe’s reports offer valuable understanding of your unique sleep patterns. Explore your sleep genetics at 23andMe.com/MattWalker for 10% off your service.

    As always, if you have thoughts or feedback you’d like to share, please reach out to Matt or Eti:

    Matt: Instagram @drmattwalker, X @sleepdiplomat,

    YouTube https://www.youtube.com/@sleepdiplomatmattwalker9299

    Eti: X @etoosh, Instagram https://www.instagram.com/eti_bensimon/, or email at etoosh@gmail.com

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    1 hr and 10 mins
  • #91 Sleep, Ambien, Memory, and Alzheimer's
    Feb 3 2025

    This week, Matt Walker dives into the world of the widely used sleeping pill, Ambien (Zolpidem). He explains how Ambien, a non-benzodiazepine sedative-hypnotic, works by targeting the brain's GABA receptors, specifically the alpha-1 subunit, to induce sleep. However, this comes with consequences. Matt highlights research by Dr. Marcos Frank showing that Ambien significantly impairs memory consolidation, essentially unwiring the brain's learning processes during sleep by approximately 50%.

    Furthermore, the episode explores Ambien's impact on the glymphatic system, the brain's crucial waste removal process active during deep sleep. New research demonstrates that Ambien reduces the glymphatic system's cleaning capacity by about 32%, potentially hindering the removal of harmful proteins linked to Alzheimer's disease. While Ambien may offer a temporary solution for insomnia, these findings underscore the importance of natural, restorative sleep for long-term brain health. The discussion advocates for such alternative treatments as Cognitive Behavioral Therapy for Insomnia (CBTI) that address sleep issues without compromising essential neural functions.

    Please note that Matt is not a medical doctor, and none of the content in this podcast should be considered medical advice in any way, shape, or form, nor prescriptive in any way.

    One of our sponsors this week is the biochemical electrolyte drink company LMNT, and they are very kindly offering eight free sample packs when you purchase any one of their orders at drinklmnt.com/mattwalker. LMNT is an electrolyte sports drink that I can get behind - it's created from the basis of science, and it has no sugar, no coloring, and no artificial ingredients – all qualities that are so important to maintaining your blood biochemical balance. If you want to give LMNT a try, just head on over to drinklmnt.com/mattwalker and get your eight free samples with your first purchase.

    Matt will be the first to tell you that launching his sleep-related merchandise sales was incredibly smooth, thanks to our new sponsor Shopify and their integrated sales and inventory system. And now, just for you, Shopify is generously offering an exclusive trial at shopify.com/mattwalker. Whether it's online or in-person sales, Shopify simplifies it all. So, be sure to stop in at shopify.com/mattwalker to start your exclusive journey now!

    As a health fanatic, Matt’s kryptonite has always been bread. Then he discovered Hero Bread: zero net carbs, zero sugar, and packed with fiber! For years, he’s enjoyed their fluffy loaves (his favorite topped with tomatoes, balsamic, and parmesan). Now, you can try it too! Hero Bread offers a delicious variety of healthy bread options, from tortillas and wraps to bagels and dinner rolls. Ready to enjoy bread again? Get 10% off your order at hero.co using code MATTWALKER.

    As always, if you have thoughts or feedback you’d like to share, please reach out to Matt:

    Instagram @drmattwalker

    X @sleepdiplomat

    YouTube: https://www.youtube.com/@sleepdiplomatmattwalker9299

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    39 mins

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