Drs Matteo Bassetti and Antoni Torres explore the early response to patients with severe COVID-19 and how treatment options have progressed since 2020.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/989637). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for healthcare professionals.

Resources

Coronavirus Disease 2019 (COVID-19) Treatment & Management https://emedicine.medscape.com/article/2500114-treatment

Dexamethasone in Hospitalized Patients With Covid-19 https://pubmed.ncbi.nlm.nih.gov/32678530/

Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-analysis https://pubmed.ncbi.nlm.nih.gov/32876694/

Predictive Factors of Six-week Mortality in Critically Ill Patients With SARS-CoV-2: A Multicenter Prospective Study https://pubmed.ncbi.nlm.nih.gov/35461665/

Procalcitonin (PCT) https://emedicine.medscape.com/article/2096589-overview

C-reactive Protein https://emedicine.medscape.com/article/2086909-overview

Ferritin https://emedicine.medscape.com/article/2085454-overview

D-dimer https://emedicine.medscape.com/article/2085111-overview

Performance of Pneumonia Severity Index and CURB-65 in Predicting 30-day Mortality in Patients With COVID-19 https://pubmed.ncbi.nlm.nih.gov/32553714/

Understanding the Role of ACE-2 Receptor in Pathogenesis of COVID-19 Disease: A Potential Approach for Therapeutic Intervention https://pubmed.ncbi.nlm.nih.gov/34176080/

Acute Respiratory Distress Syndrome (ARDS) https://emedicine.medscape.com/article/165139-overview

Driving Pressure, Mediation Analysis, and Spontaneous Breathing https://www.medscape.com/viewarticle/848731

Effect of Viral Storm in Patients Admitted to Intensive Care Units With Severe COVID-19 in Spain: A Multicentre, Prospective, Cohort Study https://pubmed.ncbi.nlm.nih.gov/37116517/

A Living WHO Guideline on Drugs for Covid-19 https://pubmed.ncbi.nlm.nih.gov/32887691/

Therapeutic Management of Hospitalized Adults With COVID-19 https://www.covid19treatmentguidelines.nih.gov/management/clinical-management-of-adults/hospitalized-adults--therapeutic-management/

Remdesivir and Survival Outcomes in Critically Ill Patients With COVID-19: A Multicentre Observational Cohort Study https://pubmed.ncbi.nlm.nih.gov/36596315/

Triple Combination Therapy With Two Antivirals and Monoclonal Antibodies for Persistent or Relapsed SARS-CoV-2 Infection in Immunocompromised Patients https://pubmed.ncbi.nlm.nih.gov/36976301/

COVID-19 Treatment: Investigational Drugs and Other Therapies https://emedicine.medscape.com/article/2500116-overview#a3