Featuring perspectives from Dr Nicole Lamanna, including the following topics:

• Introduction (0:00)
• Case: A man in his late 60s with IGHV-mutated chronic lymphocytic leukemia (CLL) (trisomy 12) and progressive adenopathy — Bhavana (Tina) Bhatnagar, DO (1:22)
• Case: A woman in her mid 70s with IGHV-unmutated, del(13q) CLL and fatigue — Erik Rupard, MD (19:57)
• Case: A woman in her mid 80s with del(13q) CLL under watchful waiting develops progressive symptoms — Shams Bufalino, MD (30:00)
• Case: A woman in her early 60s diagnosed with small lymphocytic leukemia (SLL) now with disease progression on ibrutinib — Warren S Brenner, MD (33:08)
• Current role of pirtobrutinib; CAR T-cell therapy; Richter’s transformation — Dr Brenner (36:04)
• Case: A man in his mid 40s with SLL who received second-line venetoclax/rituximab — Yanjun Ma, MD (50:01)

CME information and select publications

Featuring a slide presentation and related discussion from Dr Emanuela Palmerini, including the following topics:

• Background, diagnosis and disease course of tenosynovial giant cell tumor (TGCT) (0:00)
• Clinical data supporting systemic therapy for TGCT (10:19)
• Clinical data on emerging therapies for TGCT (17:28)
• Conclusion and future directions for TGCT (22:02)

CME information and select publications

Featuring an interview with Dr Emanuela Palmerini, including the following topics:

• Pathology, clinical presentation, diagnosis and workup of tenosynovial giant cell tumor (TGCT) (0:00)
• Local therapies for and surgical management of TGCT (20:28)
• Available systemic therapies for TGCT (30:31)
• Investigational agents under development for TGCT (49:13)
• Patient case presentations (55:54)

CME information and select publications

Featuring perspectives from Dr Sarah B Goldberg, Dr Brad S Kahl, Dr Sagar Lonial, Dr Joyce O’Shaughnessy, Dr Noopur Raje, Dr Joshua K Sabari, Dr Matthew R Smith, Dr Sonali M Smith, Dr Sandy Srinivas and Dr Seth Wander, including the following topics:

• Introduction (0:00)
• Updates in Chronic Lymphocytic Leukemia and Mantle Cell Lymphoma — Dr Kahl (1:10)
• Updates in Diffuse Large B-Cell Lymphoma and Follicular Lymphoma — Dr S Smith (33:32)

CME information and select publications

Featuring perspectives from Dr Sarah B Goldberg, Dr Brad S Kahl, Dr Sagar Lonial, Dr Joyce O’Shaughnessy, Dr Noopur Raje, Dr Joshua K Sabari, Dr Matthew R Smith, Dr Sonali M Smith, Dr Sandy Srinivas and Dr Seth Wander, including the following topics:

• Introduction (0:00)
• Role of Hormonal Therapy in Prostate Cancer Management — Dr M Smith (10:54)
• Other Available and Emerging Therapeutic Approaches — Dr Srinivas (37:03)

CME information and select publications

Optimizing Therapy for Patients with Hormone Receptor-Positive Metastatic Breast Cancer Harboring PI3K/AKT/PTEN Pathway Abnormalities — Hope S Rugo, MD

CME information and select publications

Featuring perspectives from Dr Komal Jhaveri and Dr Hope S Rugo, including the following topics:

• Introduction: PI3K/AKT/PTEN Pathway and Resistance to Endocrine Therapy (0:00)
• First-Line Therapy for HR-Positive Metastatic Breast Cancer (mBC) Harboring PI3K/AKT/PTEN Mutations (7:04)
• Treatment Options for Recurrent mBC with PI3K/AKT/PTEN Mutations (24:11)
• Beyond the Guidelines Survey (35:36)
• Faculty Case Presentations (51:27)

CME information and select publications

Featuring perspectives from Dr Sarah B Goldberg, Dr Brad S Kahl, Dr Sagar Lonial, Dr Joyce O’Shaughnessy, Dr Noopur Raje, Dr Joshua K Sabari, Dr Matthew R Smith, Dr Sonali M Smith, Dr Sandy Srinivas and Dr Seth Wander, including the following topics:

• Introduction (0:00)
• Nontargeted Therapy for Lung Cancer — Dr Goldberg (9:07)
• Targeted Therapy for Non-Small Cell Lung Cancer — Dr Sabari (51:19)

CME information and select publications