Ninja Nerds,

Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we dive deep into Lymphoma, breaking down its pathogenesis, clinical presentation, and the latest advancements in treatment. We explore the key differences between Hodgkin and Non-Hodgkin Lymphoma, examining the role of Reed-Sternberg cells, CD markers, and genetic mutations that define these malignancies.

Our discussion includes high-yield diagnostic tools like lymph node biopsy, flow cytometry, PET/CT imaging, and molecular studies, helping you differentiate between indolent and aggressive subtypes. We also analyze cutting-edge treatments, including immunotherapy, targeted monoclonal antibodies (e.g., rituximab), chemotherapy regimens like R-CHOP, and the role of stem cell transplantation in refractory cases.

Additionally, we cover disease progression, prognostic factors, and complications such as tumor lysis syndrome and secondary malignancies. Whether you’re studying for boards, preparing for clinical rotations, or just love hematology-oncology, this episode is packed with high-yield pearls you don’t want to miss!

Enjoy the episode and support us below! 🔬🔥

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Ninja Nerds,

Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Chronic Leukemias, focusing on their pathogenesis, clinical features, and modern treatment strategies. We compare Chronic Myeloid Leukemia (CML) and Chronic Lymphocytic Leukemia (CLL), discussing the role of BCR-ABL in CML and the implications of smudge cells and monoclonal B-cell proliferation in CLL. Our conversation covers key diagnostic tools such as PCR, flow cytometry, and blood smear findings, as well as cutting-edge treatment options like tyrosine kinase inhibitors (TKIs) for CML and targeted monoclonal antibody therapy for CLL. We also discuss disease progression, complications like Richter transformation, and indications for therapy in asymptomatic patients. This high-yield episode is perfect for both exam prep and clinical application—enjoy and support us below!

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Ninja Nerds,

Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we dive deep into Acute Leukemias, breaking down their pathophysiology, clinical presentation, and management. We explore the key differences between Acute Myeloid Leukemia (AML) and Acute Lymphoblastic Leukemia (ALL), focusing on the genetic mutations, risk factors, and cellular mechanisms driving these malignancies. Our discussion includes high-yield diagnostic approaches such as peripheral blood smear, bone marrow biopsy, flow cytometry, and cytogenetic analysis. We also cover essential treatment strategies, including induction chemotherapy, targeted therapies, and hematopoietic stem cell transplantation (HSCT), while highlighting critical complications like tumor lysis syndrome and leukostasis. This episode is packed with clinically relevant insights and board exam pearls—tune in and support us below!

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Ninja Nerds!

Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Myeloproliferative Neoplasms, covering their pathophysiology, clinical presentation, and management. We discuss Polycythemia Vera, Essential Thrombocythemia, Chronic Myeloid Leukemia, and Primary Myelofibrosis, focusing on key mutations like JAK2, CALR, and BCR-ABL. Our discussion includes diagnostic tools such as peripheral blood smear, bone marrow biopsy, and laboratory markers like erythropoietin levels, leukocyte alkaline phosphatase, and BCR-ABL testing. We also review treatment options, including tyrosine kinase inhibitors, cytoreductive therapy, and JAK inhibitors, as well as complications like thrombosis, bleeding, and transformation to acute leukemia. This episode provides a high-yield review for exams and clinical practice. Enjoy the episode, and support us below!

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Ninja Nerds!

Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we take a closer look at Plasma Cell Disorders, focusing on their pathophysiology, clinical features, and management. Topics include the mechanisms behind multiple myeloma, monoclonal gammopathy of undetermined significance (MGUS), and Waldenström macroglobulinemia, as well as the role of paraproteins and their clinical implications. We discuss diagnostic approaches such as serum protein electrophoresis (SPEP), immunofixation, and bone marrow biopsy, along with treatment options like proteasome inhibitors, immunomodulatory drugs, and monoclonal antibodies. We also explore complications like hypercalcemia, renal impairment, anemia, and bone lesions, ensuring a high-yield overview for exams and clinical practice. Enjoy the episode, and support us below!

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Ninja Nerds!
Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Antiplatelets, Anticoagulants, and Thrombolytics, focusing on their mechanisms and clinical uses. Topics include the pharmacology of antiplatelet agents such as aspirin and P2Y12 inhibitors, the role of anticoagulants like heparins, direct oral anticoagulants (DOACs), and warfarin in preventing thromboembolic events, and the use of thrombolytics like tPA in acute ischemic stroke and myocardial infarction. We also discuss strategies for managing bleeding risks, reversal agents, and clinical considerations for optimizing anticoagulation therapy. Enjoy the episode, and support us below!

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Ninja Nerds!

Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we discuss Hypercoagulable States, covering key disorders and their clinical significance. Topics include Antiphospholipid Syndrome (APLS), its role in thrombosis and pregnancy loss; Factor V Leiden Mutation, the most common inherited thrombophilia; and Prothrombin Gene Mutation and its increased clotting risk. We also explore Protein C and S Deficiency, Antithrombin Deficiency, and acquired states like Cancer-Associated Thrombosis, Heparin-Induced Thrombocytopenia (HIT), and Paroxysmal Nocturnal Hemoglobinuria (PNH). Tune in to learn more, and support us below!

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Ninja Nerds!

Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Coagulopathy, focusing on key bleeding and clotting disorders. Topics include Hemophilia A and B, their genetic causes, and modern treatments; Von Willebrand Disease (vWD), the most common inherited bleeding disorder; and Heparin-Induced Coagulopathy, with its paradoxical effects. We also cover Acquired Factor VIII Inhibitors in autoimmune and malignancy settings, Vitamin K Deficiency as a cause of bleeding, Disseminated Intravascular Coagulation (DIC) and its management challenges, and coagulopathy in Cirrhosis, linking liver dysfunction to bleeding and thrombosis. Enjoy the episode, and support us below!

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