In this episode, we are thrilled to host Dr. Pankaj Kapahi, a renowned expert in the realm of aging and gerontology. With a prolific academic journey that began at the University of Manchester under the guidance of Tom Kirkwood, and later took him to work alongside esteemed researchers like Seymour Benzer at Caltech and Michael Karin at the University of California, San Diego, Dr. Kapahi's career has been marked by pioneering research and profound discoveries. Currently associated with the Buck Institute since 2004, Dr. Kapahi's accolades include over 80 scientific papers, three patents, and a slew of awards that bear testament to his dedication and expertise in the field. Among his honors are the Eureka Award from the National Institute on Aging, the New Scholar Award from the Ellison Medical Foundation, the Glenn Award for Research in Biological Mechanisms of Aging, and several others. Apart from his research, Dr. Kapahi is also lauded for introducing the first master’s degree course in gerontology at the Buck Institute and his contributions to esteemed journals like Aging Cell, Aging, and PLOS Genetics. In this podcast episode, Dr. Kapahi delves deep into: The impact and benefits of Dietary Restriction (DR) as a method to extend lifespan and counteract age-related diseases. The parallels between the lifespan-extending effects of inhibiting the TOR pathway and the effects of DR in organisms like D. melanogaster, S. cerevisiae, and C. elegans. The ongoing efforts in the Kapahi lab to comprehend how organisms gauge nutrient status to influence their health and vulnerability to diseases. An insightful exploration of advanced glycation end products - their formation, their detrimental effects on our health, the variety found within the body, and the foods that are rich in these compounds. Fascinating results from experiments on model organisms when the detoxification process of advanced glycation end products was expedited. Join us for a captivating journey into the intricate mechanisms of aging and the potential interventions that promise a longer, healthier life. Don't forget to like, share, and subscribe for more enlightening conversations on the Longevity India Podcast!