Drs Michael J. Mauro and Jorge E. Cortes discuss developments in the therapeutic landscape of chronic myeloid leukemia, complexities of resistance, and the potential for treatment-free remission.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/989026). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Chronic Myelogenous Leukemia (CML) https://emedicine.medscape.com/article/199425-overview

Tyrosine Kinase Inhibitors https://www.ncbi.nlm.nih.gov/books/NBK563322/

Chronic Myelogenous Leukemia (CML) Treatment Protocols https://emedicine.medscape.com/article/2005453-overview

Monitoring Molecular Response in Chronic Myeloid Leukemia https://pubmed.ncbi.nlm.nih.gov/20960522/

Accelerated Phase Chronic Myelogenous Leukemia https://www.cancer.gov/publications/dictionaries/cancer-terms/def/accelerated-phase-chronic-myelogenous-leukemia

The 5th Edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms https://pubmed.ncbi.nlm.nih.gov/35732831/

International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: Integrating Morphologic, Clinical, and Genomic Data https://pubmed.ncbi.nlm.nih.gov/35767897/

International Chronic Myeloid Leukemia Foundation https://www.cml-foundation.org/

Sokal Score for CML https://reference.medscape.com/calculator/559/sokal-score-for-cml

Treatment-Free Remission: The New Goal in CML Therapy https://pubmed.ncbi.nlm.nih.gov/34618317/

Hematopoietic Stem Cell Transplantation (HSCT) https://emedicine.medscape.com/article/208954-overview

Imatinib (Rx) https://reference.medscape.com/drug/gleevec-imatinib-342239

BCR-ABL Fusion Gene https://www.cancer.gov/publications/dictionaries/cancer-terms/def/bcr-abl-fusion-gene

Ph-like Acute Lymphoblastic Leukemia https://pubmed.ncbi.nlm.nih.gov/28972016/

Next-Generation Sequencing for BCR-ABL1 Kinase Domain Mutation Testing in Patients With Chronic Myeloid Leukemia: A Position Paper https://pubmed.ncbi.nlm.nih.gov/31801582/

ASXL1 Gene https://medlineplus.gov/genetics/gene/asxl1/

Asciminib https://reference.medscape.com/drug/scemblix-asciminib-4000255

The Specificity of Asciminib, a Potential Treatment for Chronic Myeloid Leukemia, as a Myristate-Pocket Binding ABL Inhibitor and Analysis of Its Interactions With Mutant Forms of BCR-ABL1 Kinase https://pubmed.ncbi.nlm.nih.gov/33096322/

ATP-Competitive Inhibitors Modulate the Substrate Binding Cooperativity of a Kinase by Altering Its Conformational Entropy https://pubmed.ncbi.nlm.nih.gov/35905186/

Ponatinib (Rx) https://reference.medscape.com/drug/iclusig-ponatinib-999800