Structures of Indifference examines an Indigenous life and death in a Canadian city and what it reveals about the ongoing history of colonialism. At the heart of this story is a 34-hour period in September 2008. During that day and half, Brian Sinclair, a middle-aged, non-status Anishinaabeg resident of Manitoba's capital city, arrived in the emergency room of the Health Sciences Centre, Winnipeg's major downtown hospital, was left untreated and unattended to, and ultimately died from an easily treatable infection. His death reflects a particular structure of indifference born of and maintained by colonialism.

McCallum and Perry present the ways in which Sinclair, once erased and ignored, came to represent diffuse yet singular and largely dehumanized ideas about Indigenous people, modernity, and decline in cities. This story tells us about ordinary indigeneity in the City of Winnipeg through Sinclair's experience and restores the complex humanity denied him in his interactions with Canadian health and legal systems, both before and after his death.

Structures of Indifference completes the story left untold by the inquiry into Sinclair’s death, the 2014 report of which omitted any consideration of underlying factors, including racism and systemic discrimination.